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The Science of Collagen


Collagen makes up the main structural protein of the different connective tissues present in animals. Collagen is mostly found in fibrous tissues, such as tendons and ligaments, and is also abundant in the cornea, cartilage, bones, blood vessels, the gut, and intervertebral discs. Collagen together with elastin and hyaluronic acid is the major insoluble fibrous protein found in the extra celluIar matrix of the skin. The total protein mass in mammals is made up of the collagen family which consists of 28 different proteins accounting for 25% – 35% and it plays a pivotal role in the structure of several tissues, such as skin and bones, which provides rigidity and integrity.

What type of collagen is best for beauty and skin specifically?

Marine collagen is the most compatible with human tissue and is made from wild fish skins. The best collagen supplement for skin, hair and nails is low-molecular weight marine collagen peptides. Numerous types of collagen are found in the body.

Colla-genie is made up of a collagen which is consistent with about 90% of your body’s overall collagen.

Where is each type of collagen found?

Where is each type of collagen found?

Type I– skin, tendons, blood vessel walls, organs, bone(main component of the organic part of the bone)- secreted by fibroblasts.

Type II– cartilage- synthesized by the chondrocyte cells.

Type III– reticulate, commonly found alongside type I- secreted by reticular cells. This is the collagen of granulation tissue and is also produced by fibroblasts before the type I collagen is synthesized. Reticular fiber is also found in the skin, intestines, artery walls, uterus and liver.

Type IV– major component of the basement membrane, which is the specialized sheet-like extracellular matrix of multicellular tissues that exists around certain cell types(eg. Skeletal muscle cells, smooth muscle cells, heart muscle cells and adipocytes).


The Skin Structure

The skin comprises of three (3) distinct layers. The epidermis is a visible and outermost protective layer. The dermis is a structural layer that contains collagen and elastin and the subcutaneous is the deepest layer.

The human body’s protection from the external environment is in fact the skin, which is the largest organ and which is made up of a complex structure. The multiple skin layers including structural proteins and other vital components are responsible for maintaining normal functioning and a healthy appearance of the skin.

The aging process of skin is natural and inevitable but we can certainly assist in being proactive rather than reactive by ensuring that we supplement collagen within our bodies. Internal and external factors can affect our skin. Internal factors which are genetics unfortunately cannot be controlled by us but the external factors can be and those include: sun exposure (UV damage), poor diet, stress, environmental pollution, alcohol and smoking.

From the age of 25, our skin’s collagen production decreases. As we age, our skin gradually loses structural components that are key, over and above collagen, this includes, elastin and hyaluronic acid. The body’s ability to deal with damaging free radicals, produced as a result of the external environment like sun exposure and internal cellular metabolism also declines. Unless enough antioxidants are present, free radicals can accumulate leading to oxidative stress in the skin.

Collagen and elastin is broken down and this results in the loss of the skin’s support structure and then the skin will gradually lose smoothness, fullness and elasticity and this then causes fine lines and wrinkles to appear and causes the skin to become drier, less radiant and could result in healing taking longer, due to the slower cellular renewal. It is necessary for you to follow an effective skincare routine, diet and lifestyle in order to protect the youthfulness and beauty of your skin.

In order to supplement your diet and to rejuvenate your skin and maintain the youthfulness, taking Colla-genie will assist all this from within.

Vitamin C Importance

Hydroxyproline is critical for collagen stability and is created by modifying normal proline amino acids after the collagen chain is built. This reaction requires vitamin C to assist in the addition of oxygen. Unfortunately, we cannot make vitamin C within our bodies but luckily the Vitamin C intake in our diets is generally adequate.


Collagen plays an important and beneficial role in building and maintaining the healthy connective tissue throughout the digestive tract.

In order to prevent a “leaky gut”, you need to ensure that your digestive tract is strong as well as the stomach lining.  


The intestinal lining determines the substances that enter the bloodstream through the digestive tract.

If your gut is healthy, the intestines are then resistant to harmful substances.

When the barrier lining of your intestine is damaged, you could experience Leaky Gut and this would then result in inflammation, as the waste particles and food are then able to pass into the bloodstream.

What substances can enter the bloodstream from the digestive tract are determined by the intestinal lining.

The intestines are resistant to harmful substances in a HEALTHY gut.

Chronic conditions found to be resultant from Leaky Gut are:

  • auto-immune conditions
  • food sensitivities
  • mental health conditions
  • skin conditions

Symptoms of Leaky Gut are”

  • Bloating Gas
  • Irritable Bowel Syndrome (IBS)
  • Stomach Cramps
  • Sensitivity to foods which have a high sugar content and are gluten and wheat based

Foods that may trigger Leaky Gut are:

  • Artificial sweeteners
  • Baked goods
  • Beverages
  • Dairy products
  • Gluten-containing grains
  • Junk food
  • Processed meats
  • Refined oils
  • Sauces
  • Snack foods


The further possible breakdown of the intestinal lining can be prevented by Collagen Peptides and they will also provide anti-inflammatory properties in the gut.


Intestinal inflammation could possibly be prevented by all the complex amino acids contained in Collagen, which also helps to repair.

The main amino acid in the Collagen that assists to fight the leaky gut and the inflammation is Glutamine, which aims at the inflammation, which is part of the opening of tight junctions, resultant from oxidative stress in the intestine.

Glutamine also can assist in curbing cravings of sugar and alcohol.


Tissue bodies can be fortified and healed by Amino Acids like Glycine and Proline. Collagen comprises of these two Amino Acids.

These Amino Acids boost our body’s natural ability to repair if there is damage to the intestinal lining. Our stomach and intestinal lining can begin healing by the Collagen protein that enhances production of new smooth muscle cells and these will also assist in preventing toxins and other particles leaking into your bloodstream.

Glutathione is made from glycine (amino acid) and as an important anti-oxidant, it helps protect your cells.

The Collagen helps create new cells and preserve existing cells, which then keeps your gut healthy and works on the healing.

Leaky Gut syndrome becomes easier to manage if the body can heal the damage in the intestine (tight junctions).


Support, structure, and regulation of the production of body tissues essentially requires Collagen as a supplement. Included are organs in our digestive system which are affected by leaky gut. Other organs are required to take up some of any extra stress that we put on our bodies if the intestines may become compromised.

Amino acids also help to keep other organs healthy, as do new smooth muscle cells which work to heal and repair intestinal linings.

If the entire digestive system is in distress, leaky gut symptoms may be assisted by Collagen, which can also provide the necessary support.

In order to get things sorted out and on track, the added support then gives the body time and the resources needed to do so.


The abundance of amino acids in Collagen supplementation is the major requirement in the GI Tract.

Certain production of non-essential amino acids is decreased once we reach our twenties and production of Collagen decreases. We do not always make as many as we need, although we produce the same naturally.

By taking Collagen daily, we will ensure that we are obtaining all the amino-acids that are needed, even though our diet should help to make some of these up, the Collagen ensures that you get the correct dosage, which assists for leaky gut symptoms and your overall health.

The Collagen protein’s impressive amino acid profile is made up of 18 different types. Our digestive system will be much healthier
when more amino-acids are introduced into the bodies and the healthier our bodies are, the better our bodies begin to work.

Our bodies will begin picking up their natural production of amino-acids to keep us healthy, once we take Collagen that improves our health.

A problem with leaky gut syndrome is that it endeavors to make up for the loss of the nutrients. Due to our tight junctions that are opening, toxins and food particles leak out and we also allow the important nutrients to escape through the intestinal lining.


Collagen is a hydrophilic molecule which is a molecule that is attracted to water and acidic molecules. Thus, when Collagen is ingested, this will then be attached to water and the stomach acid, which then surrounded by the molecules, will assist in the breakdown of any food eaten.

Contents move through our GI Tract more smoothly and at a quicker rate due to the movement through our GI Tract and as a result of holding water.

Digestion is as a result of this process then more efficient and due to the more effective digestion of our food, as the particles move through our intestines, less particles would be lost, which results in less particles leaking into our bloodstream.

Collagen 101

The long strands of collagen are broken down into small peptides once Gelatin is hydrolyzed further. The Collagen peptides are soluble and can be digested easily and absorbed by our body. Once consumed, within a few hours, over 90% of the collagen peptides appear in our bloodstream and are then delivered effectively to their site of action in the body.

The Collagen peptides also act as messengers to the target tissue, which then influences its function, like triggering the synthesis and reorganization of new Collagen.

Collagen peptides are made by cutting the large collagen molecule into a diverse mix of smaller parts, called peptides. The peptides are characterized by high levels of the amino acids glycine, proline and hydroxyproline – together these represent around 50% of the total. Hydroxyproline is particular to collagen and stable bonds are formed with other amino acids. The resulting peptides provide collagen peptides with unique and effective bioactive properties.


Collagen is produced by different cells in our body.

These cells use specific amino acids as the building blocks for the long chains which are wound together to the large Collagen triple helix. The strong fibers that provide structural tissue support, flexibility and the ability to withstand forces are as a result from the organization of the several helices.

The skin's dry mass content is made up of 75% Collagen. Collagen fibres are a key component of the skin’s structure and provide the infrastructure for elastin, which maintains skin elasticity and for the hyaluronic acid which traps moisture.

The strong fibrous connective tissues that connect muscles to bones are the Tendons. The tendons' role during muscle contraction is to transmit forces and withstand tension. Tendons are made up of 85% collagen type 1 and of proteoglycans.

Joint cartilage is made up of cellular building blocks (chondrocytes), which produce an extracellular matrix, consisting of collagen and proteoglycans (mainly aggrecan). Collagen fibres make up 70% of cartilage and are responsible for its structure and strength, while proteoglycans serve as lubricant to the joint.

Collagen represents about 90% of the organic bone mass and provides the structural framework on which calcium and other minerals are anchored. The Collagen fibres also provide bone flexibility.


Collagen is vital for our bodies and the loss will have an impact and affect various conditions of our bodies.


The firmness and structure of our skin is provided by Collagen. Collagen breakdown is accelerated and production is lessened with age, which results in our skin being dehydrated and thinner and then the signs of aging become visible.


Bones get weaker and will gradually cause them to be more fragile and become breakable, due to the collagen levels and the content of minerals that decrease. 


With aging, it is harder for us to stay active, as there is wear and tear on the joint cartilage which reduces well-functioning and this will also cause joint discomfort. 


With aging, there is decreased muscle strength and function and our balance as well as the overall mobility is affected.

There is also a loss of collagen which results in a gradual loss in the connective tissue which bundles the muscle fibers into the strong and functioning muscles.